is the gstm1 null polymorphism a risk factor for primary angle-closure glaucoma among iranian population?

Is the GSTM1 null polymorphism a risk factor for primary angle-closure glaucoma among Iranian population?

Glutathione S-transferases (GSTs) are members of multigenic family which have the essential functionin cells as an antioxidant. In the present study we studied the polymorphism of GSTT1 and GSTM1 deletion genotypes in Iranian patients with primary closed angle glaucoma (PCAG) compared to healthy subjects. We conducted a study of 41 PCAG patients (24 women, 17 men) and 100 healthy participants (...

Is the GSTM1 null polymorphism a risk factor in Primary Open Angle Glaucoma?

PURPOSE To investigate the association of glutathione S-transferase (GST) GSTM1, GSTT1, and GSTP1 genes with the risk of primary open angle glaucoma (POAG) and clinical features of the disease. METHODS We conducted a case-control study that included 87 Brazilian patients with POAG and 85 healthy controls matched for age, ethnicity, and sex, whose blood samples were genotyped for polymorphisms...

Primary Angle Closure Glaucoma

Primary angle-closure glaucoma

The picture of primary angle-closure glaucoma accompanied by its shallow anterior chamber is so distinct that for many years it has evoked considerable curiosity concerning possible genetic determination. Family trees were published (Sedan and Sedan-Bauby, 1949; Waardenburg, I96I) and attempts were made to fit the inheritance into a genetic pattern-but without convincing success. Authors seemed...

GSTM1 null genotype is a risk factor for laryngeal cancer.

It remains unclear whether the Glutathione S-transferase M1 (GSTM1) null genotype influence laryngeal cancer development. This study aimed to investigate the interactions among GSTM1 genotype with regard to laryngeal cancer development. We searched online electronic databases (PubMed, EMBASE and CNKI). The strength of association between the GSTM1 genotype and laryngeal cancer risk was assessed...

Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma

Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 Glaucoma patients (41with pr...